娄筱叮教授长期以来围绕复杂生物样本，在多功能聚集体设计及应用方面取得了创新性成果。在国际核心期刊上发表/接收SCI论文174篇（高被引论文15篇）。相关研究成果已被国际知名刊物引用9000余次，H因子为57（Google Scholar）。作为第一作者或通讯作者在Chem. Soc. Rev., Acc. Chem. Res., Angew. Chem. Int. Ed.,Adv. Mater., ACS Nano, Adv. Funct. Mater., Nano Energy, Adv. Sci., Anal. Chem., Chem. Sci., Small, Biomaterials, Biosens. Bioelectron. 等国际一流学术刊物发表研究论文112篇，单通讯文章36篇。国家重点研发计划青年项目首席科学家，国家优秀青年科学基金获得者，国家高层次人才特殊支持计划青年拔尖人才，全国青联委员，中青科协理事，湖北省政协委员，湖北省青年五四奖章获得者，湖北省杰出青年基金获得者，湖北省第十二次妇女代表，湖北省青联常委&教育社科界别主委，湖北省知联会理事，湖北省青科协委员，中国生物材料学会影像材料与技术分会委员，《Chinese Chemical Letters》青年编委，湖北省“楚天学者计划”楚天学子。主持国家重点研发计划青年项目1项，国家自然科学基金优青项目1项，面上项目2项，青年项目1项，国家重点研发计划重大科学仪器设备开发专项子课题1项，湖北省自然科学基金杰青项目1项，面上项目1项，浙江省自然科学基金一般项目1项。获得国家授权发明专利12项，参编专著3部。应邀在亚洲化学年会，中国化学会年会，全国分析化学年会，全国化学生物学会议，全国电化学会议，E-MRS，海峡两岸生物医学前沿交叉学术研讨会等国内外会议上做邀请报告。 代表性学术研究成果 1. Hu, Jing-Jing, Jiang, Wenlian, Qiao, Yujuan, Mа, Qun, Du, Qiujiаo, Jiang, Jian-Hui, Lou, Xiaoding(*), Xia, Fan(*), Enzyme Regulating the Wettability of Outer Surface of Nanochannels. ACS Nano, 2023, 15 (2), 3026-3037.2. Zhang, Wei(#), Hu, Jing-Jing(#), Liu, Rui, Dai, Jun, Yuan, Lizhen, Liu, Yiheng, Chen, Bochao, Gong, Mingxing, Xia, Fan and Lou, Xiaoding(*). A peptide-conjugated probe with cleavage-induced morphological change for treatment on tumor cell membrane. Advanced Science, 2023, 2207228.3. Li, Jianqing, Zhuang, Zeyan, Lou, Xiaoding(*), Zhao, Zujin(*), and Tang, Ben Zhong. Molecular Design and Biomedical Application of AIEgens with Photochemical Activity. Chemical & Biomedical Imaging. 2023, DOI: 10.1002/advs.202207228.4. Duan, Chong(#), Hu, Jing-Jing(#), Liu, Rui, Dai, Jun, Yuan, Lizhen, Xia, Fan and Lou, Xiaoding(*). Regulating the membrane affinity of multi-module probes to address the trade-off between anchoring and internalization. Analytical Chemistry, 2023, 95 (4), 2513–2522.5. Wu, Meng(#), Xue, Liru(#), Guo, Yican, Dong, Xiaoqi, Chen, Zhaojun, Wei, Simin, Yi, Xiaoqing, Li, Yinuo, Zhang, Jinjin, Zhou, Su, Wu, Mingfu, Lou, Xiaoding(*), Dai, Jun(*), Xia, Fan(*), Wang, Shixuan(*).Microenvironmentally responsive chemotherapeutic prodrugs and CHEK2 inhibitors self-assembled micelles: protecting fertility and enhancing chemotherapy. Advanced Materials. 2023, 2210017.6. Dai, Jun(#), Hu, Jing-Jing(#), Dong, Xiaoqi(#), Chen, Biao, Dong, Xiyuan, Liu, Rui, Xia, Fan and Lou, Xiaoding(*). Deep downregulation of PD-L1 by caged peptide-conjugated AIEgen/miR-140 nanoparticles for enhanced immunotherapy. Angewandte Chemie International Edition, 2022, 61 (18), e202117798.7. Li, Jianqing(#), Dai, Jun(#), Zhuang, Zeyan(#), Meng, Zijuan, Hu, Jing-Jing, Lou, Xiaoding(*), Xia, Fan, Zhao, Zujin, Tang, BenZhong. Combining PD-L1 blockade with immunogenic cell death induced by AIE photosensitizer to improve antitumor immunity. Biomaterials. 2022, 291, 121899.8. Long, Zi(#), Hu, Jing-Jing(#), Yuan, Lizhen, Duan, Chong, Dai, Jun, Zhen, Shijie, Zhao, Zujin, Lou, Xiaoding(*) and Xia, Fan. A cell membrane-anchored nanoassembly with self-reporting property for enhanced second near-infrared photothermal therapy. Nano Today, 2021, 41, 101312.9. Duan, Chong(#), Hu, Jing-Jing(#), Liu, Rui, Dai, Jun, Duan, Mojie, Yuan, Lizhen, Xia, Fan and Lou, Xiaoding(*). Spatial order of functional modules enabling diverse intracellular performance of fluorescent probes. Angewandte Chemie International Edition, 2021, 60 (33),18280–18288.10. Jia, Hui, Ding, Defang, Hu, Jingjing, Dai, Jun, Yang, Juliang, Li Guogang(*), Lou, Xiaoding(*) and Xia Fan(*). AIEgen-based lifetime-probes for precise furin quantification and identification of cell subtypes. Advanced Materials, 2021, 33 (45), 2104615.11. Jiang, Ruming(#), Dai, Jun(#), Dong, Xiaoqi, Wang, Quan, Meng, Zijuan, Guo, Jingjing, Yu, Yongjiang, Wang, Shixuan, Xia, Fan, Zhao, Zujing(*), Lou, Xiaoding(*) and Tang, Ben Zhong(*). Improving image-guided surgical and immunological tumor treatment efficacy by photothermal and photodynamic therapies based on a multifunctional NIR AIEgen, Advanced Materials, 2021, 33 (22), 2101158.12. Yi, Xiaoqing(#), Hu, Jing-Jing(#), Dai, Jun, Lou, Xiaoding(*), Zhao, Zujin, Xia, Fan(*) and Tang, Ben Zhong(*). Self-guiding polymeric prodrug micelles with two aggregation-induced emission photosensitizers for enhanced chemo-photodynamic therapy, ACS Nano, 2021, 15 (2), 3026-3037.13. Wu, Xia, Wu, Jun, Dai, Jun, Chen, Biao, Chen, Zhe, Wang, Shixuan, Wu, Feng, Lou, Xiaoding(*), Xia, Fan, Role of cell cycle progression on analyzing telomerase in cancer cells based on aggregation-induced emission luminogens. National Science Review, 2021, 8 (6), nwaa306.14. Yi, Xiaoqing(#), Hu, Jing-Jing(#), Dai, Jun, Lou, Xiaoding(*), Zhao, Zujin, Xia, Fan(*), Tang, Ben Zhong(*),Self-Guiding Polymeric Prodrug Micelles with Two Aggregation-Induced Emission Photosensitizers for Enhanced Chemo-Photodynamic Therapy, ACS Nano, 2021, 15, 3026-3037.15. Yang, Juliang(#), Dai, Jun(#), Wang, Quan, Cheng, Yong, Guo, Jingjing, Zhao, Zujin, Hong, Yuning, Lou, Xiaoding(*) and Xia, Fan, Tumor Triggered Disassembly of Multiple‐Agent‐Therapy Probe for Efficient Cellular Internalization, Angewandte Chemie International Edition, 2020, 59, 20405-20410. 16. Dai, Jun(#),Cheng, Yong(#),Wu, Jun(#), Wang Quan, Wang Wenwen, Yang, Juliang, Zhao, Zujin, Lou,Xiaoding(*), Xia, Fan(*), Wang, Shixuan(*), Tang, Ben Zhong, Modular peptide probe for pre/intra/postoperative therapeutic to reduce recurrence in ovarian cancer. ACS Nano 2020, 14: 14698-14714. 17. Dai, Jun(#), Li, Yinghao(#), Long, Zi, Jiang, Ruming, Zhuang, Zeyan, Wang, Zhiming, Zhao, Zujin(*), Lou, Xiaoding(*), Xia, Fan and Tang, Ben Zhong(*), Efficient near-infrared photosensitizer with aggregation-induced emission for imaging-guided photodynamic therapy in multiple xenograft tumor models, ACS Nano, 2020, 14, 854-866. 18. Lou, Xiaoding(#), Huang, Yu (#), Yang, Xian, Zhu, Hai, Heng, Liping, and Xia, Fan(*), External Stimuli Responsive Liquid-Infused Surfaces Switching between Slippery and Non-slippery States: Fabrications and Applications,Advanced Functional Materials, 2020, 30, 1901130.19. Xia, Fan, Wu, Jun, Wu, Xia, Hu, Qinyu, Dai, Jun, Lou, Xiaoding(*), Modular design of peptide- or DNA-modified AIEgens probes for biosensing applications, Accounts of Chemical Research, 2019, 52, 3064-3074. 20. Cheng, Yong(#), Sun, Chunli(#), Liu, Rui(#), Yang, Juliang, Dai, Jun, Zhai, Tianyou, Lou, Xiaoding(*), Xia, Fan(*), A multifunctional peptide-conjugated AIEgen for efficient and sequential targeted gene delivery into the nucleus, Angewandte Chemie International Edition, 2019, 58, 5049-5053. 21. Wu, Feng(#), Wu, Xia(#), Duan, Zhijuan, Huang, Yu, Lou, Xiaoding(*) and Xia, Fan(*), Biomacromolecule-Functionalized AIEgens for Advanced Biomedical Studies, Small, 2019, 1804839.22. Lou, Xiaoding(#), Song, Yongjun(#), Liu, Rui, Cheng, Yong, Dai, Jun, Chen, Qing, Gao, Pengcheng, Zhao, Zujin and Xia, Fan (*) Enzyme and AIEgens Modulated Solid-State Nanochannels: In Situ and Noninvasive Monitoring of H2O2 Released from Living Cells, Small Methods, 2019, 1900432. 23. Hu, Rong, Chen, Bin, Wang, Zhiming, Qin, Anjun, Zhao, Zujin(*), Lou, Xiaoding(*) and Tang, Ben Zhong(*), Intriguing "chameleon" fluorescent bioprobes for the visualization of lipid droplet-lysosome interplay, Biomaterials, 2019, 203, 43-51. 24. Zhen, Shijie(#), Yi, Xiaoqing(#), Zhao, Zujin(*), Lou, Xiaoding(*), Xia, Fan and Tang, Ben Zhong(*), Drug delivery micelles with efficient near-infrared photosensitizer for combined image-guided photodynamic therapy and chemotherapy of drug-resistant cancer, Biomaterials, 2019, 119330. 25. Cheng, Yong(#), Dai, Jun(#), Sun, Chunli(#), Liu, Rui, Zhai, Tianyou, Lou, Xiaoding(*), Xia, Fan(*), An intracellular H2O2-responsive AIEgen for the peroxidase-mediated selective imaging and inhibition of inflammatory cells,Angewandte Chemie International Edition, 2018, 57, 3123-3127. 26. Wang, Xudong(#), Dai, Jun(#), Min, Xuehong, Yu, Zhihua, Cheng, Yong, Huang, Kaixun, Yang, Juliang, Yi, Xiaoqing, Lou, Xiaoding (*), Xia, Fan(*), DNA-Conjugated Amphiphilic Aggregation-Induced Emission Probe for Cancer Tissue Imaging and Prognosis Analysis, Analytical Chemistry, 2018, 90, 8162-8169. 27. Cheng, Yong, Sun, Chunli, Ou, Xiaowen, Liu, Bifeng, Lou, Xiaoding(*), and Xia, Fan(*), Dual-targeted peptide-conjugated multifunctional fluorescent probe with AIEgen for efficient nucleus-specific imaging and long-term tracing of cancer cells, Chemical Science, 2017, 8, 4571-4578. 28. Zhuang, Yuan(#), Shang, Chunli(#), Lou, Xiaoding(*), Xia, Fan(*), Construction of AIEgens-based bioprobe with two fluorescent signals for enhanced monitor of extracellular and intracellular telomerase activity, Analytical Chemistry,2017, 89, 2073-2079.29. Duan, Ruixue, Lou, Xiaoding(*), Xia, Fan(*), The development of nanostructure assisted isothermal amplification in biosensors, Chemical Society Reviews, 2016, 45, 1738-1749. 30. Gao, Pengcheng, Hu, Lintong, Liu, Nannan, Yang, Zekun, Lou, Xiaoding(*), Zhai, Tianyou(*), Li, Huiqiao, Xia, Fan(*), Functional “janus” annulus in confined channels, Advanced Materials, 2016, 28, 460-465. 主持或参加科研项目及人才计划项目情况1. 中组部“万人计划”青年拔尖人才、2022/01-2024/12、180万元、在研、主持。2. 国家重点研发计划纳米科技专项，2020YFA0211200、微纳米尺度调控的POCT 生物传感器件在子宫内膜癌筛查中的应用研究、2021/01-2025/12、444万元、在研、主持。3. 国家自然科学基金优秀青年基金，21722507、化学生物传感、2018/01-2020/12、130万元、结题、主持。4. 湖北省自然科学基金杰出青年基金, 2019CFA043、光电双信号微纳米器件在肿瘤微环境单细胞分析中的应用、2019/01-2021/12、20万元、在研、主持。5. 国家自然科学基金面上项目，21974128、模块化多肽-AIE探针对高侵袭性乳腺癌细胞中亚细胞器的长效示踪、2020/01-2023/12、63万元、在研、主持。6. 国家自然科学基金面上项目，21574048、亲疏水可调DNA-AIE高分子复合探针的构建及其传感性能研究、2016/01-2019/12、65万元、结题、主持。7. 国家重点研发计划重大科学仪器设备开发专项，2016YFF0100800、2017/01-2019/12、基于微流控高通量芯片的新型高灵敏传感系统开发及应用、100万元、结题、子课题负责人。8. 浙江省自然科学基金一般项目，LY18B050002、基于多标志物联合技术的微纳米器件的构筑及其在乳腺癌早期检测中的应用、2018/01-2020/12、10万、结题、主持。9. 国家自然科学基金青年项目，21405054、微纳米限域空间内聚集诱导发光分子的组装行为在生物/化学传感器中的应用、2015/01-2017/12、25万元、结题、主持。10. 湖北省自然科学基金面上项目，2014CFB1012、聚集诱导发光分子在微纳米孔道中传感性能的研究、2014/01-2015/12、3万元、结题、主持。