Doctoral Degree in Science
Faculty of Higher Institutions
Wuhan University
Gender:Female
Date of Employment:2017-07-01
Business Address:Faculty of Materials Science and Chemistry, China University of Geosciences (Wuhan)
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娄筱叮，中国地质大学（武汉），教授，博士生导师，国家优秀青年科学基金、国家“万人计划”青年拔尖人才获得者，国家重点研发计划青年项目首席科学家。主要研究方向为蛋白质活细胞分析及调控，场效应晶体管生物传感器件的构筑及应用等。近五年以通讯作者发表论文68篇。包括Nat. Chem.、J. Am. Chem. Soc.、Angew. Chem. Int. Ed.、Anal. Chem.、Adv. Mater.、ACS Nano、Nano Lett. 等。全部论文引用10000余次，H指数60（Google Scholar）。获评中国分析测试协会科学技术奖CAIA奖一等奖（第一完成人）、湖北省青年五四奖章、湖北省自然科学一等奖（第三完成人）。担任中青科协理事、全国青联委员、湖北省政协委员。担任中国生物材料学会影像材料与技术分会委员、中国人体健康科技促进会临床检验科学技术转化专业委员会委员、中国感光学会光学传感与诊疗专委会委员。
研究方向
活细胞蛋白质分析
场效应晶体管生物传感器---疾病早期检测
固态/蛋白纳米孔道---精准蛋白质分析
代表性学术研究成果
1. Hu, Liming, Cao, Wenbing, Jiang, Yihaofan, Cai, Wenkang, Lou, Xiaoding(*), Liu, Tao(*). Designing Artificial Fluorescent Proteins and Biosensors by Genetically Encoding Molecular Rotor-based Amino Acids. Nature Chemistry, 2024, 16, 1960–1971
2. Li, Yuxuan, Su, Yeyu, Wang, Haoyu, Xie Yuanzhe, Wang, Xin, Chang, Liying, Jing, Yanbo, Zhang, Jiayi, Ma, Jun-An, Jin, Hongwei, Lou, Xiaoding(*), Peng, Qian(*), Liu, Tao(*). Computation-Guided Discovery of Diazole Monosubstituted Tetrazines as Optimal Bioorthogonal Tools. Journal of the American Chemical Society, 2024, 146, 39, 26884–26896.
3. Dai, Jun, Hu, Yuxin, Liu, Weiyong, Liu, Hong, Wang, Shixuan, Xia, Fan, Lou, Xiaoding(*). Cell-sensing Analogue Nanopore for Rapid Detection of Protein-Related Targets. Angewandte Chemie International Edition, 2024, e202421721.
4. Wu, Xia, Hu, Jing-Jing, Duan, Chong, Liu, Rui, Xia, Fan, Lou, Xiaoding(*). A Universal and Programmable Platform based on Fluorescent Peptide-Conjugated Probes for Detection of Proteins in Organelles of Living Cells. Angewandte Chemie International Edition, 2024, 17(63), e202400766.
5. Hu, Jing-Jing, Yuan, Lizhen, Zhang, Yunfan, Kuang, Jing, Song, Wen, Lou, Xiaoding(*), Xia, Fan, Yoon, Juyoung(*). Photo-Controlled Calcium Overload from Endogenous Sources for Tumor Therapy. Angewandte Chemie International Edition, 2024, 63, 9, e202317578.
6. Hu, Jing-Jing, Lin, Niya, Zhang, Yunfan, Xia, Fan, Lou, Xiaoding(*). Nanofibers in Organelles: From Structure Design to Biomedical Applications. Angewandte Chemie International Edition, 2023, 63, e202313139.
7. Qiao, Yujuan, Hu, Jing-Jing, Hu, Yuxin, Duan, Chong, Jiang, Wenlian, Ma, Qun, Hong, Yuning, Huang, Wei-Hua, Xia, Fan, Lou, Xiaoding(*). Detection of Unfolded Cellular Proteins Using Nanochannel Array with Probe-Functionalized Outer-Surfaces. Angewandte Chemie International Edition, 2023, 62, e202309671.
8. Wu, Meng, Xue, Liru, Guo, Yican, Dong, Xiaoqi, Chen, Zhaojun, Wei, Simin, Yi, Xiaoqing, Li, Yinuo, Zhang, Jinjin, Zhou, Su, Wu, Mingfu, Lou, Xiaoding(*), Dai, Jun(*), Xia, Fan(*), Wang, Shixuan(*). Microenvironmentally responsive chemotherapeutic prodrugs and CHEK2 inhibitors self-assembled micelles: protecting fertility and enhancing chemotherapy. Advanced Materials, 2023, 2210017.
9. Dai, Jun, Hu, Jing-Jing, Dong, Xiaoqi, Chen, Biao, Dong, Xiyuan, Liu, Rui, Xia, Fan and Lou, Xiaoding(*). Deep downregulation of PD-L1 by caged peptide-conjugated AIEgen/miR-140 nanoparticles for enhanced immunotherapy. Angewandte Chemie International Edition, 2022, 61 (18), e202117798.
10. Duan, Chong, Hu, Jing-Jing, Liu, Rui, Dai, Jun, Duan, Mojie, Yuan, Lizhen, Xia, Fan and Lou, Xiaoding(*). Spatial order of functional modules enabling diverse intracellular performance of fluorescent probes. Angewandte Chemie International Edition, 2021, 60 (33),18280–18288.
主持或参加科研项目及人才计划项目情况
1. 国家自然科学基金面上项目，22474131，转子阵列探针应用于衰老细胞中蛋白质翻译后修饰过程的动态监测，2025/01-2028/12，50万元、在研、主持。
2. 湖北省自然科学基金计划(创新群体项目)，2024AFA001，针对女性恶性肿瘤的多通道超高灵敏度传感器件，50万元、在研、主持。
3. 深圳市基础研究专项(自然科学基金)基础研究面上项目，JCYJ20230807113706013，基于表面定向偶联技术的高性能POCT传感器件的构建及在蛋白质翻译后修饰检测中的应用，2024/01-2026/12，30万元、在研、主持。
4. 中组部“万人计划”青年拔尖人才、2022/01-2024/12、180万元、在研、主持。
5. 国家重点研发计划纳米科技专项，2020YFA0211200、微纳米尺度调控的POCT 生物传感器件在子宫内膜癌筛查中的应用研究、2021/01-2025/12、444万元、在研、主持。
6. 国家自然科学基金优秀青年基金，21722507、化学生物传感、2018/01-2020/12、130万元、结题、主持。
7. 湖北省自然科学基金杰出青年基金, 2019CFA043、光电双信号微纳米器件在肿瘤微环境单细胞分析中的应用、2019/01-2021/12、20万元、在研、主持。
8. 国家自然科学基金面上项目，21974128、模块化多肽-AIE探针对高侵袭性乳腺癌细胞中亚细胞器的长效示踪、2020/01-2023/12、63万元、在研、主持。
9. 国家自然科学基金面上项目，21574048、亲疏水可调DNA-AIE高分子复合探针的构建及其传感性能研究、2016/01-2019/12、65万元、结题、主持。
10. 国家重点研发计划重大科学仪器设备开发专项，2016YFF0100800、2017/01-2019/12、基于微流控高通量芯片的新型高灵敏传感系统开发及应用、100万元、结题、子课题负责人。
11. 浙江省自然科学基金一般项目，LY18B050002、基于多标志物联合技术的微纳米器件的构筑及其在乳腺癌早期检测中的应用、2018/01-2020/12、10万、结题、主持。
12. 国家自然科学基金青年项目，21405054、微纳米限域空间内聚集诱导发光分子的组装行为在生物/化学传感器中的应用、2015/01-2017/12、25万元、结题、主持。
13. 湖北省自然科学基金面上项目，2014CFB1012、聚集诱导发光分子在微纳米孔道中传感性能的研究、2014/01-2015/12、3万元、结题、主持。
[1] 2003.9 to 2004.6
Hubei Engineering University | Chemistry Pedagogy | Undergraduate (Bachelor’s degree) | Bachelor's Degree
[2] 2004.9 to 2007.6
Wuhan University | Chemistry Base Class | Exchange Student
[3] 2007.9 to 2012.6
Wuhan University | Organic Chemistry | Doctoral Degree in Education | Doctoral Degree in Science
[1] 2017.1 to Now
Faculty of materials science and chemistry | China University of Geosciences
[2] 2016.4 to 2016.10
Department of Physics | University of California, Santa Barbara
[3] 2014.11 to 2016.12
School of Chemistry and Chemical Engineering | Huazhong University of Science and Technology
[4] 2013.8 to 2014.10
School of Chemistry and Chemical Engineering | Huazhong University of Science and Technology
[5] 2012.8 to 2013.7
Department of Chemistry | Hong Kong University of Science and Technology
[1] 蛋白质在活细胞内变化快，浓度差异大，导致难以精准测量，是活细胞中蛋白质检测中的科学技术难点。娄筱叮教授针对目前活细胞中蛋白质检测方法的局限性，选取抗体识别位点处的多肽序列，设计穿过细胞膜屏障的多肽序列，合成光稳定性优异的信号分子，使用多种方法共价连接功能模块，开发模块化多肽探针系统，实现了复杂活细胞环境中蛋白质的精准识别与定量、动态分析，并取得以下成果：1）调节氨基酸序列的阳离子密度和疏水性，增加穿过细胞膜屏障的能力，提高探针入胞效率；2）优化氨基酸序列的构象和空间构型，增强与靶标蛋白质的亲和力，增强识别特异性；3）合成光谱匹配，可后修饰的聚集型信号分子，调控信号输出模块设计原理，降低背景干扰
[1]2017.3 to Now
Standing Committee of the 13th Committee of Hubei Youth Federation
[2]2017.1 to Now
Member of Hubei Youth Science Association
[3]2018.3 to Now
Delegates of the 12th Hubei Provincial Women's Congress
[4]2018.11 to Now
Member of the first Session of Imaging Materials and Technology Branch, Chinese Society of Biomaterials
[5]2019.12 to Now
Member of China Youth Association for Science and Technology
[6]2019.6 to Now
Chinese Chemical Letters
[7]2020.1 to Now
Member of the All-China Youth Federation
[8]2020.1 to Now
Member of "Youth Propaganda Group" of Hubei Province to study and implement the spirit of the Fifth Plenary Session of the 19th CPC Central Committee
[9]2022.1 to Now
The 14th Standing Committee of Hubei Youth Federation & Chairman of Education and Social Science Sector
[10]2023.1 to Now
Member of the Hubei CPPCC
[11]2022.1 to Now
Hubei Advanced Young workers in Chemistry and Chemical Industry
[12]2022.1 to 2025.12
Member of the China Association for the Promotion of Human Health Science and Technology (CAHST) Clinical Laboratory Science and Technology Translation Committee
[13]2022.3 to Now
Director of Hubei Zhi Lian Association
[14]2022.3 to Now
Member of Imaging Materials and Technology Branch, Chinese Society of Biomaterials
