个人简历
刘春生，男，辽宁兴城人，2011年8月参加工作，博士学位。现任环境学院教授，博士生导师，“地大学者”学科骨干人才（A类）。刘春生教授的主要研究方向为生态毒理学，主要研究工作是利用环境化学、分子毒理学、生态学和流行病学等技术方法，研究环境中典型污染物对野生生物和人群健康的影响，并开展区域环境下致毒污染物的甄别和溯源工作。先后培养博士后5人，博士研究生10人，硕士研究生18人。在环境科学主流刊物ES＆T等发表第一或通讯作者研究论文60余篇，论文被引用3000余次。在2014和2016年分别获得湖北省“楚天学子”和国家自然科学基金优秀青年基金的资助，担任Environmental Research副主编。
教育背景：
2008年9月—2011年6月 中科院水生生物研究所 生态毒理学博士
2006年9月—2008年9月 中科院水生生物研究所 生态毒理学（硕转博）
2002年9月—2006年7月 东北大学 生物工程（本科）
工作经历：
2022年7月—至今：中国地质大学（武汉），教授，博导
2016年8月—2022年6月：华中农业大学，教授，博导
2013年12月—2016年8月：华中农业大学，研究员，博导
2013年1月—2013年12月：新加坡国立大学，博后
2011年8月—2012年12月：南京大学， 助理研究员
主持或参加课题情况：
（1）国家重点研发计划，主要环境污染物对个体发育和代谢的影响及关键机制研究，2022年11月-2027年10月，参加。
（2）国家自然科学基金面上项目，梁子湖高龄达氏鲌早亡成因解析及致毒物质甄别，2024年1月-2027年12月，主持。
（3）国家自然科学基金面上项目，内质网应激在TDCIPP致土著鲫胚胎发育毒性中的作用及调控机制，2021年1月至2024年12月，主持。
（4）国家重点研发计划，村镇社区环境监测及修复关键技术研发，2019年11月至2022年12月，参加。
（5）国家自然科学基金面上项目，环境相关浓度TDCIPP暴露对土著鲫鱼的发育繁殖毒性研究，2019年1月至2022年12月，主持。
（6）国家重点研发项目，化学品快速分级与确证技术研究，2017年7月-2020年12月，参加。
（7）国家自然科学基金优秀青年基金，水生态毒理学，2017年1月-2019年12月，主持。
（8）国家自然科学基金青年基金，建立斑马鱼胚胎胁迫通路基因分析平台研究典型有机磷溴代阻燃剂发育毒性分子机制，2013年1月-2015年12月，主持。
代表性学术论文（第一/通讯作者）：
(62) Yongkang Zhang, Yuanjun Jiang, Qian Sun, Meng Li, Sheng Chen, Jingyu Liang, Chunsheng Liu* (2023). Full sexual maturity-cycle exposure to environmentally relevant concentrations of 17beta-estradiol decreases reproductive capacity of zebrafish, Journal of Environmental Sciences, 137, 580-592.
(61) Zichen Yu, Yongkang Zhang, Ren Kong, Yongjie Xiao, Boqun Li, Chunsheng Liu*, Liqin Yu* (2023). Tris(1,3-dichloro-2-propyl) phosphate inhibits early embryonic development by binding to GSK-3beta protein in zebraifsh, Aquatic Toxicology, 260:106588.
(60) 王云泽，袁思亮，孔任，钱址松，李博群，刘春生* （2022）。有机磷酸酯阻燃剂2-乙基己基二苯基磷酸酯多代暴露对大型溞生殖、发育以及相关基因转录的影响，杭州师范大学学报（自然科学版），21:6。
(59) 杨淳翔，刘春生* （2022）。环境相关浓度五氯苯酚全生命周期暴露对大型溞的毒性效应研究，生态毒理学报，3,244-255。
(58) Jun Li, Qingzhao Jin, Shaoyun Li, Yunze Wang, Siliang Yuan, Sheng Chen, Zihan Zhang, Chunsheng Liu* (2023). Effects of profenofos on the growth, reproduction, behavior, and gene transcription of Daphnia magna, Environmental Science and Pollution Research, 30, 74928-74938.
(57) Meng Li, Jiamin Fei, Zihan Zhang, Qian Sun, Chunsheng Liu* (2022). Organophosphate esters in Chinese rice: occurrence, distribution, and human exposure risks, Science of the Total Environment, 862: 160915.
(56) Yongkang Zhang, Qiaolin Xu, Qian Sun, Ren Kong, Hao Liu, Xun'e Yi, Zhengqi Liang, Robert J. Letcher, Chunsheng Liu* (2022). Ustiloxin A inhibits proliferation of renal tubular epithelial cells in vitro and induces renal injury in mice by disrupting structure and respiratory function of mitochondria, Journal of Hazardous Materials, 448:130791.
(55) Qian Sun, Zhisong Qian, Hao Liu, Yongkang Zhang, Xun'e Yi, Ren Kong, Shiyang Cheng, Jianguo Man, Lu Zheng, Junbin Huang, Guanyong Su, Robert J. Letcher, John P. Giesy, Chunsheng Liu* (2022). Occurrence and translocation of ustiloxins in rice false smut-occurred paddy fields, Hubei, China, Environmental Pollution, 307:119460.
(54) Chunsheng Liu*, Kai Huang, Zihan Zhang, Chunxiang Yang, Yongkang Zhang, Meng Li* (2022). Growth retardation in Silver Carp (Hypophthalmichthys molitrix) in the middle reaches of the Yangtze River and its possible causal agents, ACS ES&T Water, 2, 2422-2430.
(53) Ren Kong, Chunxiang Yang, Kai Huang, Guixin Han, Qian Sun, Yongkang Zhang, Hui Zhang*, Robert J. Letcher, Chunsheng Liu* (2022). Application of agricultural pesticides in a peak period induces an abundance decline of metazoan zooplankton in a lake ecosystem, Water Research, 2022, 224.
(52) Chengqian Liang, Jian Wu, Kai Huang, Ren Kong, Yongkang Zhang, Qian Sun, Chunsheng Liu* (2022). Environmentally Relevant Concentrations of Tris (1,3-dichloro-2-propyl) Phosphate Induced a Female-Biased Osteotoxicity in Crucian Carp (Carassius auratus). Environmental Science & Technology Letters, 9, 5, 439-445.
(51) Qian Sun, Hao Liu, Yongkang Zhang, Xun’e Yi, Ren Kong, Shiyang Cheng, Jianguo Man, Lu Zheng, Junbin Huang, Guanyong Su, Robert J. Letcher, John P. Giesy, Chunsheng Liu* (2022). Global distribution of ustiloxins in rice and their male-biased hepatotoxicity. Environmental Pollution, 301, 118992.
(50) 李涵，李俊，刘春生*（2021）。4,4-DDT全生命周期暴露对大型溞（Daphnia magna）生长、生殖、心率、行为、存活及基因转录的影响，生态毒理学报，3， 179-191.
(49) Yu Li, Kai Huang, Jieqiong Jiang, Yue Xiao, Lihui An, Shiyi Zhang, Qiyue Kang, Ruichao Chen, Yingting Jia, Xiaohua Zhang, Chunsheng Liu*, Jianying Hu* (2021). Tris(1,3-dichloro-2-propyl) phosphate induces mass mortality of Crucian carp (Carassius carassius) embryos in Taihu lake. Environmental Science & Technology, 55, 8108-8118.
(48) 李晓东，袁思亮，李俊，刘春生* （2021）。17β-雌二醇（E2）对大型溞（Daphnia magna）生殖、发育和相关基因转录的影响。生态毒理学报，15，5。
(47) Ya Zhu, Dandong Yang, Xinbin Duan, Yongkang Zhang, Daqing Chen, Zhiyuan Gong, Chunsheng Liu* (2021). Perfluorooctane sulfonate promotes doxycycline-induced liver tumor progression in male KrasV12 transgenic zebrafish. Environmental Research, 196, 110962.
(46) Yongkang Zhang, Xun’e Yi, Kai Huang, Qian Sun, Ren Kong, Sheng Chen, Chengqian Liang, Meng Li, Robert J. Letcher, Chunsheng Liu* (2021). Tris(1,3-dichloro-2-propyl) phosphate reduces growth hormone expression via binding to growth hormone releasing hormone receptors and inhibits the growth of Crucian carp. Environmental Science & Technology, 55, 8108-8118.
(45) Qian Sun, Hao Liu, Yongkang Zhang, Ren Kong, Xun’e Yi, Chunsheng Liu* (2021). Detection of ustiloxin A in urine by ultra-high-performance liquid chromatography-tandem mass sepctrometry coupled with two-step solid-phase extraction. Journal of Chromatography B, 1181, 122916.
(44) Ren Kong, Qian Sun, Shiyang Cheng, Jie Fu*, Wen Li, Robert J. Letcher, Chunsheng Liu* (2021). Uptake, excretion and toxicity of titanate nanotubes in three stains of free-living ciliates of the genus Tetrahymena. Aquatic Toxicology, 233, 105790.
(43) Sheng Chen, Xiaodong Li, Han Li, Siliang Yuan, Jun Li, Chunsheng Liu* (2021). Greater toxic potency of bisphenol AF than bisphenol A in growth, reproduction, and transcription of genes in Daphnia magna. Environmental Science and Pollution Research, 28, 25218-25227.
(42) Siliang Yuan, Chengqian Liang, Wen Li, Robert J. Letcher, Chunsheng Liu* (2021). A comprehensive system for detection of behavioral change of D. magna exposed to various chemicals. Journal of Hazardous Materials, 402, 123731.
(41) Wen Li, Siliang Yuan, Qian Sun, Chunsheng Liu* (2020). Toxicity of tris(2-chloroethyl) phosphate in Daphnia magna after lifetime exposure: changes in growth, reproduction, survival and gene transcription. Ecotoxicology and Environmental Safety, 200, 110769.
(40) Hui Hao, Yao Dang, Sheng Chen, Qian Sun, Ren Kong, Shiyang Cheng, Chunsheng Liu* (2020). Effects of triphenyl phosphate on ciliate protozoa Tetrahymena thermophila following acute exposure and sub-chronic exposure. Aquatic Toxicology, 222, 110757.
(39) Hui Hao, Siliang Yuan, Shiyang Cheng, Qian Sun*, John P. Giesy, Chunsheng Liu* (2020). Effects of tris (2-chloroethyl) phosphate (TCEP) on growth, reproduction and gene transcription in the protozoan Tetrahymena thermophila. Aquatic Toxicology, 222, 105477.
(38) Sheng Chen, Zhiyuan Gong, Robert J. Letcher, Chunsheng Liu* (2020). Promotion effect of liver tumor progression in male kras transgenic zebrafish induced by tris(1,3-dichloro-2-propyl) phosphate. Ecotoxicology and Environmental Safty, 191, 110220.
(37) Sheng Chen, Yao Dang, Zhiyuan Gong, Robert J. Letcher, Chunsheng Liu* (2019). Progression of liver tumor was promoted by tris(1,3-dichloro-2-propyl) phosphate through the induction of inflammatory responses in krasV12 transgenic zebrafish. Environmental Pollution, 255, 113315.
(36) Shiyang Cheng, Hao Liu, Qian Sun, Ren, Kong, Robert J. Letcher, Chunsheng Liu* (2019). Occurrence of the fungus mycotoxin, ustiloxin A, in surface waters of paddy fields in Enshi, Hubei, China, and toxicity in Tetrahymena thermophila. Environmental Pollution, 251, 901-909.
(35) Yao Dang, Qian Sun, Robert J. Letcher, Chunsheng Liu* (2018). Unexpected observations: exposure to aromatase inhibitor prochloraz did not alter vitellogenin content in zebrafish ova, but did inhibit growth of larval offspring. Environmental Science & Technology Letters, 5, 629-634.
(34) Rui Zhang, Xiaoxiang Wang, Xuesheng Zhang, Junjiang Zhang, Xiaowei Zhang, Xiao Shi, Doug Crump, Robert J. Letcher, John P. Giesy, Chunsheng Liu* (2018). Down-regulation of hspb9 and hspb11 contributes to wavy notochord in zebrafish embryos following exposure to polychlorinated diphenylsulfides. Environmental Science & Technology, 52, 12829-12840.
(33) Rui Zhang, Xiaoxiang Wang, Xuesheng Zhang, Chao Song, Robert J. Letcher, Chunsheng Liu* (2018). Polychlorinated diphenylsulfides activate aryl hydrocarbon receptor 2 in zebrafish embryos: potential mechanism of developmental toxicity. Environmental Science & Technology, 52, 4402-4412.
(32) Ya Zhu, Daohui Lin, Dandong Yang, Yali Jia, Chunsheng Liu* (2018). Environmentally relevant concentrations of the flame retardant tris(1,3-dichloro-2-propyl) phosphate change morphology of female zebrafish. Chemosphere, 212, 358-364.
(31) Yao Dang, Fei’er Wang, Chunsheng Liu* (2018). Real-time PCR array to study the effects of chemicals on the growth hormone/insulin-like growth factors (GH/IGF) axis of zebrafish embryos/larvae. Chemosphere, 207, 365-376.
(30) Yongkang Zhang, Guanyong Su, Meng Li, Shuying Li, Qiangwei Wang, Guonian Zhu, Robert J. Letcher, Chunsheng Liu* (2018). Chemical and biological transfer: which one is responsible for the maternal transfer toxicity of tris(1,3-dichloro-2-propyl) phosphate in zebrafish? Environmental Pollution, 243, 1376-1382.
(29) Yongkang Zhang, Meng Li, Shuying Li, Qiangwei Wang, Guonian Zhu, Guanyong Su, Robert J. Letcher, Chunsheng Liu* (2018). Exposure to tris(1,3-dichloro-2-propyl) phosphate for two generations decreases fecundity of zebrafish at environmentally relevant concentrations. Aquatic Toxicology, 200, 178-187.
(28) Siliang Yuan, Han Li, Yao Dang, Chunsheng Liu* (2018). Effects of riphenyl phosphate on growth, reproduction and transcription of genes of Daphnia magna. Aquatic Toxicology, 195, 58-66.
(27) Han Li, Siliang Yuan, Guanyong Su, Meng Li, Qiangwei Wang, Guonian Zhu, Robert J. Letcher, Yufei Li, Zhihua Han, Chunsheng Liu* (2017). Whole-life-stage characterization in the basic biology of Daphnia magna and effects of TDCIPP on growth, reproduction, survival and transcription of genes. Environmental Science & Technology, 51, 13967-13975.
(26) Guangyu Li, Huike Ye, Guanyong Su, Zhihua Han, Congxin Xie, Bingsheng Zhou, Robert J. Letcher, John P. Giesy, Hongxia Yu, Chunsheng Liu* (2017). Establishment of a three-step method to evaluate effects of chemicals on development of zebrafish embryo/larvae. Chemosphere, 186, 209-217.
(25) Ya Zhu, Guanyong Su, Dandong Yang, Yongkang Zhang, Liqin Yu, Yufei Li, John P. Giesy, Robert J. Letcher, Chunsheng Liu* (2017). Time-dependent inhibitory effects of tris(1,3-dichloro-2-propyl) phosphate on growth and transcription of gene involved in the GH/IGF axis, but not the HPT axis, in female zebrafish. Environmental Pollution, 229, 470-478.
(24) Liqin Yu, Yali Jia, Guanyong Su*, Yongkai Sun, Robert J. Letcher, John P. Giesy, Hongxia Yu, Zhihua Han, Chunsheng Liu* (2017). Parental transfer of tris(1,3-dichloro-2-propyl) phosphate and transgenerational inhibition of growth of zebrafish exposed to environmentally relevant concentrations. Environmental Pollution, 220, 196-203.
(23) Shiyang Cheng, Jing Li, Guanyong Su, Robert J. Letcher, John P. Giesy, Chunsheng Liu* (2016). A reagent-free screening assay for evaluation of the effects of chemicals on the proliferation and morphology of Hela-GFP cells. Environmental Science & Technology Letters, 3, 322-326.
(22) Jing Li, Xufa Ma, Guanyong Su*, John P. Giesy, Yuan Xiao, Bingsheng Zhou, Robert J. Letcher, Chunsheng Liu* (2016). Multigenerational effects of tris(1,3-dichloro-2-propyl) phosphate on the free-living ciliate protozoa Tetrahymena thermophile exposed to environmentally relevant concentrations and after subsequent recovery. Environmental Pollution, 218, 50-58.
(21) Yao Dang, Jianghua Wang, John P. Giesy, Chunsheng Liu* (2016). Responses of the zebrafish hypothalamic-pituitary-gonadal-liver axis PCR array to prochloraz are dependent on timing of sampling. Aquatic Toxicology, 175, 154-159.
(20) Chunsheng Liu*, Guanyong Su, John P. Giesy, Robert J. Letcher, Guangyu Li, Ira Agrawal, Jing Li, Liqin Yu, Jianghua Wang, Zhiyuan Gong* (2015). Acute exposure to tris(1,3-dichloro-2-propyl) phosphate (TDCIPP) causes hepatic inflammation and leads to hepatotoxicity in zebrafish. Scientific Reports, 6:19045.
(19) Ya Zhu, Xufa Ma, Guanyong Su*, Liqin Yu, Robert J. Letcher, Jie Hou, Hongxia Yu, John P. Giesy, Chunsheng Liu* (2015). Environmentally relevant concentrations of the flame retardant tris(1,3-dichloro-2-propyl) phosphate inhibit growth of female zebrafish and decrease fecundity. Environmental Sciences & Technology, 49, 14579-14587.
(18) Han Li, Guanyong Su, Ming Zou, Liqin Yu, Robert J. Letcher, Hongxia Yu, John P. Giesy, Bingsheng Zhou, Chunsheng Liu* (2015). Effects of tris(1,3-dichloro-2-propyl) phosphate on growth, reproduction, and gene transcription of Daphnia magna at environmentally relevant concentrations. Environmental Sciences & Technology, 49, 12975-12983.
(17) Jing Li, John P. Giesy, Liqin Yu, Guangyu Li*, Chunsheng Liu* (2015). Effects of tris(1,3-dichloro-2-propyl) phosphate (TDCPP) in Tetrahymena Thermophila: targeting the ribosome. Scientific Reports, 5:10562.
(16) Yao Dang, John P. Giesy, Jianghua Wang*, Chunsheng Liu* (2015). Dose-dependent compensation responses of the hypothalamic-pituitary-gonadal-liver axis of zebrafish exposed to the fungicide prochloraz. Aquatic Toxicology, 160, 69-75.
(15) Liqin Yu, Zhihua Han*, Chunsheng Liu* (2015). A review on the effects of PBDEs on thyroid and reproduction systems in fish. General and Comparative Endocrinology, 219, 64-73. invited review
(14) Zhihua Han, Qiangwei Wang, Jie Fu, Hongshan Chen, Ye Zhao, Bingsheng Zhou, Zhiyuan Gong, Si Wei, Jun Li, Hongling Liu, Xiaowei Zhang, Chunsheng Liu*, Hongxia Yu* (2014). Multiple bio-analytic methods to reveal possible molecular mechanisms of developmental toxicity in zebrafish embryos/larvae exposed to tris(2-butoxyethyl) phosphate. Aquatic Toxicology, 150, 175-181.
(13) Jie Fu, Changpo Zhao, Yupeng Luo, Chunsheng Liu*, George Z. Kyzas, Yin Luo, Dongye Zhao, Shuqing An, Hailiang Zhu* (2014). Heavy metals in surface sediments of the Jialu River, China: their relations to environmental factors. Journal of Hazardous Materials, 270, 102-109.
(12) Chunsheng Liu*, Hongyan Xu, Siew Hong Lam, Zhiyuan Gong* (2013). Selection of reliable biomarkers from PCR array analysis using relative distance computational model: methodology and proof-of-concept study. PLoS ONE, e83954.
(11) Chunsheng Liu, Hongxia Yu, Xiaowei Zhang (2013). Zebrafish embryos/larvae for rapid determination of effects on hypothalamic-pituitary-thyroid (HPT) and hypothalamic-pituitary-interrenal (HPI) axis: mRNA expression. Chemosphere, 93, 2327−2332.
(10) Jie Fu, Jian Han, Bingsheng Zhou, Zhiyuan Gong, Eduarda M. Santos, Xiaojing Huo, Weiling Zheng, Hongling Liu, Hongxia Yu, Chunsheng Liu* (2013). Toxicogenomic responses of zebrafish embryos/larvae to tris(1,3-dichloro-2-propyl) phosphate (TDCPP) reveal possible molecular mechanisms of developmental toxicity. Environmental Sciences & Technology, 47, 10574−10582.
(9) Chunsheng Liu*, Qiangwei Wang, Kang Liang, Jingfu Liu, Bingsheng Zhou, Xiaowei Zhang, Hongling Liu, John P. Giesy, Hongxia Yu* (2013). Effects of tris(1,3-dichloro-2-propyl) phosphate and triphenyl phosphate on receptor-associated mRNA expression in zebrafish embryos/larvae. Aquatic Toxicology, 128-129, 147-157.
(8) Qiangwei Wang, Kang Liang, Jingfu Liu, Lihua Yang, Yongyong Guo, Chunsheng Liu*, Bingsheng Zhou* (2013). Exposure of zebrafish embryos/larvae to TDCPP alters concentrations of thyroid hormones and transcriptions of genes involved in the hypothalamic-pituitary-thyroid axis. Aquatic Toxicology, 126, 207-213.
(7) Chunsheng Liu, Wei Yan, Bingsheng Zhou, Yongyong Guo, Hongling Liu, Hongxia Yu, John P. Giesy, Jianghua Wang, Guangyu Li, Xiaowei Zhang (2012). Characterization of a bystander effect induced by the endocrine-disrupting chemical 6-Propyl-2-thiouracil in zebrafish embryos. Aquatic toxicology, 118, 108-115 .
(6) Chunsheng Liu, Xiaowei Zhang, Jun Deng, Markus Hecker, John P. Giesy, Bingsheng Zhou (2011). Effects of prochloraz or propylthiouracil on the cross-talk between the HPG, HPA and HPT axes in zebrafish. Environmental Sciences &Technology , 45, 769-775.
(5) Chunsheng Liu, Jun Deng, Liqin Yu, Mathan Ramesh, Bingsheng Zhou (2010). Endocrine disruption and reproductive impairment in zebrafish by exposure to 8:2 FTOH fluorotelomer alcohol. Aquatic toxicology, 96, 70-76.
(4) Chunsheng Liu, Xiaowei Zhang, Hong Chang, Paul Jones, Steve Wiseman, Jonathan Naile, Markus Hecker, John P. Giesy, Bingsheng Zhou (2010). Effects of fluorotelomer alcohol 8:2 FTOH on steroidogenesis in H295R cells: Targeting the cAMP signaling cascade. Toxicology and Applied Pharmacology, 247, 222-228.
(3) Chunsheng Liu, Liqin Yu, Jun Deng, Paul K.S. Lam, Rudolf S.S. Wu, Bingsheng Zhou (2009). Waterborne exposure to fluorotelomer alcohol 6:2 FTOH alters plasma sex hormone and gene transcription in the hypothalamic-pituitary-gonadal (HPG) axis in zebrafish. Aquatic toxicology, 93, 131-137.
(2) Chunsheng Liu, Yongbing Du, Bingsheng Zhou (2007). Evaluation of estrogenic activities and mechanism of action of perfluorinated chemicals determined by vitellogenin induction in primary cultured tilapia hepatocytes. Aquatic Toxicology, 85, 267-277.
(1) Chunsheng Liu, Ke Yu, Xiongjie Shi, Jingxian Wang, Paul K.S. Lam, Rudolf S.S. Wu and Bingsheng Zhou (2007).Induction of oxidative stress and apoptosis by PFOS and PFOA in primary cultured hepatocytes of freshwater tilapia (Oreochromis niloticus). Aquatic Toxicology, 82, 135-143.
授权专利：(1) 刘春生, 孙倩, 孔任，液质联用快速测定尿液或细胞培养基中稻曲菌素A含量的方法, 2022-2-1, 国家发明专利, ZL202011416964.6。